GETTING MY BOSENTAN TO WORK

Ketoconazole Coadministration of bosentan 125 mg twice day-to-day and ketoconazole, a potent CYP3A inhibitor, greater the plasma concentrations of bosentan by close to a hundred% in typical volunteers. No dose adjustment of bosentan is essential, but amplified effects of bosentan ought to be deemed.Bosentan is a certain and aggressive antagonist at